Data mining in mass spectrometry-based proteomics studies
نویسندگان
چکیده
منابع مشابه
Computational Mass Spectrometry–Based Proteomics
Proteomics is defined as the system-wide characterization of all the proteins in an organism in terms of their sequence, localization, abundance, post-translational modifications, and biomolecular interactions. Modern proteomic investigations are increasingly quantitative and comprehensive [1]. Examples include the relative quantification of over 4,000 proteins in haploid and diploid yeast, whi...
متن کاملData Preprocessing and Filtering in Mass Spectrometry Based Proteomics
Mass spectrometry based proteomics analysis can produce many thousands of spectra in a single experiment, and much of this data, frequently greater than 50%, cannot be properly evaluated computationally. Therefore a number of strategies have been developed to aid the processing of mass spectra and typically focus on the identification and elimination of noise, which can provide an immediate imp...
متن کاملData pre-processing in liquid chromatography-mass spectrometry-based proteomics
MOTIVATION In a liquid chromatography-mass spectrometry (LC-MS)-based expressional proteomics, multiple samples from different groups are analyzed in parallel. It is necessary to develop a data mining system to perform peak quantification, peak alignment and data quality assurance. RESULTS We have developed an algorithm for spectrum deconvolution. A two-step alignment algorithm is proposed fo...
متن کاملmass spectrometry-based proteomics in the life sciences: a review
proteomics concerns itself with the characterization and function of all cellular proteins, the ultimate determinants of cellular function. mass spectrometry has emerged as the preferred method for in-depth characterization of the protein components of biological systems. using mass spectrometry, key insights into the composition, regulation and function of molecular complexes and pathways have...
متن کاملMass spectrometry–based proteomics in cell biology
The global analysis of protein composition, modifications, and dynamics are important goals in cell biology. Mass spectrometry (MS)-based proteomics has matured into an attractive technology for this purpose. Particularly, high resolution MS methods have been extremely successful for quantitative analysis of cellular and organellar proteomes. Rapid advances in all areas of the proteomic workflo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science & Technology Development Journal - Engineering and Technology
سال: 2020
ISSN: 2615-9872,2615-9872
DOI: 10.32508/stdjet.v2i4.483